Tag: Pharmaceutical

Who is Responsible for Generic Drug Safety?

In June, the US Supreme Court ruled that patients injured by generic drugs cannot successfully sue the manufacturer due to inadequate warning labels; however, the patient does have the ability to sue brand name drug makers. The Food and Drug Administration (FDA) currently does not allow generic producers to revise their product warning labels as new safety concerns are discovered. Generics are required to copy the brand-name manufacturer’s equivalent drug warning label verbatim, even if they are aware of additional risks not listed.   

Public Citizen, a national nonprofit advocacy organization, has petitioned The FDA to revise regulations, allowing generic manufacturers to update their product warning labels. In 2010, over 90% of all prescriptions filled were the generic version of the desired drug. With the rise of generic use, Public Citizen believes that these manufacturers should have the ability to revise their labels to warn their consumers of all dangers, no matter when they were discovered. “The action we are requesting would bring FDA regulation in line with the realities of the pharmaceutical market and help to ensure that drug labeling provides adequate warnings to patients based on information that comes to light after the drug is approved for marketing,” said Allison Zieve, director of Public Citizen’s Litigation Group.

The FDA is underfunded and short staffed, previously relying on brand name drug makers to identify any potential risks. Associate Justice of the U.S. Supreme Court, Samuel Alito, stated that he believes the regulation “may significantly increase the costs for generic drug manufacturers, and therefore counteract one of the objectives of the statute, which was to provide generic drugs at a low cost.” If the petition succeeds, the FDA’s limited resources and the added responsibility of monitoring the thousands of drugs on the market will cause some serious changes in the pharmaceutical market.  The Public Citizen petition asks the question, who is responsible for generic drug safety?

Sources:
http://articles.cnn.com/2011-03-30/justice/scotus.drug.safety_1_generic-drug-generic-market-generic-equivalent?_s=PM:CRIME
http://online.wsj.com/article/SB10001424053111904199404576538361710655074.html?mod=WSJ_Pharmaceuticals_leftHeadlines
http://www.law.com/jsp/cc/PubArticleCC.jsp?id=1202510496208&From_the_Experts_Brave_New_PostMensing_World
http://www.citizen.org/pressroom/pressroomredirect.cfm?ID=3406

A Safer Pharmaceutical Supply Chain – Is RFID the Answer?

Supply chain management is a business-critical process. When the business is pharmaceuticals and the product is medication, keeping the chain of custody and managing the route between supplier and end-user becomes even more important. Radio Frequency Identification (RFID) technology is a growing resource for the medical profession on the front line – and it may now be moving to the back office.

Using wireless radio waves and item tags, RFID technology can identify a person, object or product by reading its unique, numerical code. The potential for using automatic RFID to track medication from start to finish promises the potential to address counterfeit pharmaceuticals, a $32 billion industry that, according to the FDA, represents 10 percent of the global market.

RFID data can be transferred from a medication’s label to a computer system, using an RFID reader, where the data is verified and logged to help track products at various levels. This means medication can be sourced from the manufacturer to the distribution center to a pharmacy.

RFID does not yet have both feet firmly placed in the Pharmaceutical industry’s back office. The technology is not inexpensive and RFID is still gaining momentum in the medical space. However, current industry requirements are spurring the development of RFID standards and applications, which will in turn cause the need to comply with these standards. As more RFID tags are produced to manage compliance, cost will likely go down in turn.

RFID has the potential to streamline the Pharmaceutical supply chain, reduce labor costs and track product. This tracking strengthens the transparency of the supply chain, provides greater consumer protection and translates product authentication directly to patient safety.

Sources
http://direct.www.ti.com/rfid/docs/manuals/whtPapers/wp-RFID_and_PKI.pdf
http://www.tompkinsinc.com/publications/competitive_edge/articles/02-04-RFID_Pharma.asp
http://www.rfidjournal.com/article/view/1339